Honesty Is Not a Tool for Your Personal Gain. Welcome back to Mid- Week Meditations, Lifehacker’s weekly dip into the pool of stoic wisdom, and how you can use its waters to reflect on and improve your life. Welcome back to Mid- Week Meditations, Lifehacker’s weekly dip into the pool of stoic wisdom, and…Read more Read.
This selection, from Marcus Aurelius, takes aim at those who believe honesty is something to be used at advantage, or some gift to be given to those who are worthy: The rotten pretense of the man who says, ‘I prefer to be honest with you’! What are you on about, man? No need for this preface - the reality will show. It should be written on your forehead, immediately clear in the tone of your voice and the light of your eyes, just as the loved one can immediately read all in the glance of his lovers. In short, the good and honest man should have the same effect as the unwashed - anyone close by as he passes detects the aura, willy- nilly, at once.
Calculated honesty is a stiletto. There is nothing more degrading than the friendship of wolves: avoid that above all. The good, honest, kindly man has it in his eyes, and you cannot mistake him. Meditations, 1. 1. What It Means. Beginning a statement with a phrase like, “I’ll be honest with you..” or “To be frank..” or “To tell you the truth..” is not necessary when you’re an honest person. Elder Scrolls Arena Windows Vista. If you are honest and good, people will know through your personality and character.
Just by being around, everyone should be able to sense that you’re a well- meaning individual. If you’re dishonest, they’ll recognize that too.
Humans are much better lie detectors than they realize. Aurelius then refers to calculated honesty, or the selective use of honesty when it best suits you, as a “stiletto” (skalme in Greek)—but he’s not talking about shoes here. He means an assassin’s dagger with a long, slender blade intended for stabbing through leather and the slots between heavy armor to end a life in a single motion. Essentially, Aurelius is calling calculated honesty a tool used by villains who slink through the shadows and do not fight fair. In his eyes, choosing when to be honest and when to be dishonest is cowardly and false.
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Sphinx is a full-text search engine, publicly distributed under GPL version 2. Commercial licensing (eg. for embedded use) is available upon request. Connection times vary, and can take between 5 to 20 business days. That's all it says. Presumably from the date you place the order. Known Issues for Oracle SOA Products and Oracle BPM Products for 12c Release 1 (12.1.3.0.0) This document lists issues and workarounds for Oracle SOA and Oracle BPM. Free online pharmacy compare service for consumers with many brand and generic discount drugs from USA, canadian, mexican, indian and international online pharmacy. Web security tool to make fuzzing at HTTP inputs, made in C with libCurl. You can do: brute force passwords in auth forms; directory disclosure ( use PATH list to. GOVERNMENT OF PAKISTAN. IRD), Broadband Global Access Network (B-GAN), LNA (Low. G-I shall be importable as well via land route.
Each day, we make the same choice hundreds of times: whether to lie or tell the truth. It often…Read more Read. What to Take From It. Early on in our lives we learn that lying is bad. Yet, somewhere along the way, we discover that the world is complicated, and that being completely and totally honest is far more difficult than we’d hoped.
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So we lie. Now, sometimes a lie is unavoidable and for the best. There’s no real harm in saying “Everything is going to be okay” to comfort another, after all. You can’t see the future, so you can’t say that honestly—but it’s fine. The real issue isn’t fibbing occasionally, no. It’s when you choose to cling to dishonesty, to live your lies as long as it benefits you. It’s exuding an utter lack of sincerity and using brief flashes of honesty like some sort of tool to manipulate people as you see fit. One lie begets another and eventually you’ve lied so many times you start to believe them yourself.
You become them. It’s not always easy to be honest with people. We’re all guilty of telling a white lie or…Read more Read. So, what can you do? Is honesty really the best policy?
Perhaps, but nobody is perfect. Instead, let go of your fears.
The fear that you’ll be judged, the fear that you’re not good enough, the fear that someone will catch the faintest whiff of your weaknesses, and be honest. Be your authentic, sincere self, and choose to give it to people straight as often as you can. Be honest and you can live honest. If you find yourself constantly opening up your conversations with phrases like, “I’ll be honest with you..” or “To be frank..” or “To tell you the truth,” you have to wonder why.. Are you preparing them for your sincerity?
Or are you preparing yourself for something you rarely do?
FDA Storytelling—FDA Inspectional Observations & Warning Letter Citations Relating to Qualification & Validation IVT - GMPThe following FDA Form 4. Inspectional Observations and FDA Warning Letter citations are examples of significant violations of current good manufacturing practice (c. GMP) regulations for Finished Pharmaceuticals, Code of Federal Regulations Title 2. Parts 2. 10 and 2. FDA investigators at various companies.
The purpose of this supplement is to review the compiled inspectional observations and warning letter citations and learn from the GMP violations made publicly available on the FDA’s website. By studying these GMP gaps noted during an FDA inspection, one can address ways to avoid similar non- GMP compliant practices in one’s company. The intent of this supplement is not to find fault in any company. FDA inspectional observations listed on a Form FDA 4. ORA FOIA Electronic Reading Room. Some records have been redacted by FDA to remove non- public information.
As noted on the Form FDA 4. FDA representative(s) during the inspection of a facility do not represent a final FDA determination regarding a firm’s compliance. FDA warning letters are posted on the FDA website.
As noted on the website, matters described in FDA warning letters may have been subject to subsequent interaction between FDA and the letter recipient that may have changed the regulatory status of issues discussed in the letter. Some records have been redacted by FDA to remove non- public information.
Selected examples of warning letters are presented in Part I of this supplement while selected examples of inspectional observations are presented in Part II of this supplement. For guidance on how to avoid the following warning letters and inspectional observations, dowload "Conduct a Gap Analysis of a Validation Program," from IVT's 2nd Annual Validation Week Canada. Part I: FDA Warning Letters.
Part 2. 11 Subpart B – Organization and Personnel, Sec 2. Responsibilities of quality control unit. Failure to establish and follow written procedures applicable to the responsibilities of the quality control unit [2. CFR 2. 11. 2. 2(d)].
Your SOP A1. 38 entitled "Procedure for Process and Product Validations" addresses review and approval of validation protocols/reports and states that Team Quality is responsible for assuring the SOP is followed. However, during the inspection the investigators documented numerous and significant discrepancies in your Process Validation Report PCR- 0. Striztn, Rev. A., which was approved by Team Quality on December 1. For example: a. Section 5. Section 5. 2 of the report. i. Section 5. 2 of the report describes Validation Cycle A with a heat exposure ".. The results reported in Section 5.
Section 5. 2 of the report describes Validation Cycle C with a heat exposure ".. The results reported in Section 5.
Section 5. 2 of the report describes Validation Cycle D with a heat exposure ".. The results reported in Section 5. Section 5. 2 of the report describes Validation Cycle A as a".. L Type [redacted] Glass Bottle, [redacted] m.
L fill," and [redacted] type." The results reported in Section 5. L S. C. bottle, 4. L fill: a closed crimp .."b. Table 2 entitled "Executed Sterilization Cycle Parameters" reports heat exposure time as [redacted] Heat exposure time for Validation Cycle C on November 9, 2. Section 5. 2 of the report describes Validation Cycle C with a heat exposure"..
Similar discrepancies were noted in Table 2 for Validation Cycles D, E, and F.[Cytosol Laboratories, Inc., Date Issued: October 3. Failure to establish and follow written responsibilities and procedures applicable to the quality control unit [2. CFR 2. 11. 2. 2(d)]. For example: .. Written procedure 1- 0.
Validation Policy," dated 1. Pyrantel Pamoate Suspension Canine- 2. X (4. 5. 4 mg / m. L), Lot [redacted] in April 2. A planned deviation changed the compounding tank, mixer speeds and mixing times used to make this [redacted] batch of suspension product.
The Validation Department did not determine if the modification was major or minor as defined in Section 7. SOP 1- 0. 13. In addition the Validation Department did not address the need to do additional testing to assure the product was equivalent to that made by the validated process. .. The response to the second example does not address the issue of the failure to follow the validation policy SOP when a change was made in the compounding tank, mixer speeds and mixer times for the production of a lot of suspension product (Pyrantel Pamoate Canine (4. L). The response says, in the future, your firm will only make this suspension product in kettles with dual motion sweep agitation. However, your firm made one lot in Tank #8 for the purpose of process validation. We do not understand why, if First Priority determined a new mixing tank should be used for suspension products, was a lot manufactured in Tank #8? The validation consisted of collecting 3 samples, one from the top, one from the middle and one from the bottle of the tank.
The three values ranged from [redacted] mg / m. L [redacted] %) to [redacted] %). There is no discussion or explanation of the relatively low results provided with the response. If this lot was formulated for 1. GMPs, we question what happened to almost 5% of the active ingredient in the middle sample and we wonder why this lot was made using Tank #8 when your firm identified the need to change the mixing process using a kettle which has dual motion sweep agitation[First Priority, Inc., Date Issued: July 9, 2. The responsibilities and procedures applicable to the quality control unit are not fully followed.
CFR 2. 11. 2. 2(d)]During upgrading your (b)(4) system in July 2. However, your Quality Control Unit failed to follow your change control procedure (SOP- 3. December 1. 5, 1. Your firm's response indicated that your firm modified the distribution loop after updating the system in July 2. Please provide details, including a scientific rationale, of the two modifications implemented, especially for the post- inspection modifications.
Meanwhile, your response provided only one training record to showing that one person from the production department has received training. Your response did not demonstrate that other people who have been involved with the change control procedure have been trained, as well. Please clarify and provide any supportive documentation if applicable.[Laboratoire Atlas, Inc., Date Issued: June 2. Failure to have an adequate quality control unit and adequate laboratory facilities available for the quality control unit for the testing and approval (or rejection) of components, in- process materials, drug products, and all procedures or specifications impacting on the identity, strength, quality, and purity of the drug products as required by 2. CFR § 2. 11. 2. 2(a), 2.
Your quality control unit (QCU) has allowed failing product to remain in distribution, released product to the market without adequate stability data to support the expiration dates, failed to conduct adequate investigations of discrepancies, failed to adequately review all analytical data prior to release, and failed to assure adequate analytical method validations were conducted for numerous finished product test procedures. During the meeting conducted on June 1. Atlanta District's office your consultant stated that the result of the cultural assessment review conducted at the Fort Mill site revealed that upper management responsible for overseeing the QCU was "out of touch" with the events occurring, had "minimal presence", and was "largely unaware of the quality concerns in the laboratory" at the site. In addition, an investigation of the test procedure LC- 1. Quality Control Director in October 2.
Despite this finding, the Quality Control Director did not implement any corrective actions to remedy this deficiency and your company continued to use the inadequate test method.